. In rats injected with complete Freund's adjuvant (CFA) to induce chronic inflammatory pain
, we observed cells expressing phospho-ATF2-IR accumulating in the spinal dorsal horn.
As a result, there is a great need to understand the cellular processes involved in inflammatory pain
to create less toxic, less addictive, analgesic drugs," he added.
Wan, "Attenuation of mechanical but not thermal hyperalgesia by electroacupuncture with the involvement of opioids in rat model of chronic inflammatory pain
," Brain Research Bulletin, vol.
Overexpression of endothelin-1 in astrocytes, but not in endothelial cells, ameliorates inflammatory pain
response after formalin injection .
Pre-clinical studies in cell culture and in animal models of neuropathic and inflammatory pain
have shown that the molecule is effective at reducing neuronal activity and pain levels.
"Chronic inflammatory pain
can be treated with pain-killing drugs - analgesics - but these usually have an impact on the whole body and may also dull our experience of acute pain, which is actually very important as it protects us from injury.
Tzschentke, "Antinociceptive and antihyperalgesic effects of tapentadol in animal models of inflammatory pain
," Journal of Pharmacology and Experimental Therapeutics, vol.
Palmitoylethanolamide versus a nonsteroidal anti-inflammatory drug in the treatment of temporomandibular joint inflammatory pain
. J Orofac Pain.
CB1 and CB2 cannabinoid receptors are implicated in inflammatory pain
The PGB is reported to have an antinociceptive effect in neuropathic pain as well as inflammatory pain
Specifically, decreased miR-125a-3p contributes to upregulation of p38 MAPK in rat trigeminal ganglions with orofacial inflammatory pain
The hungry mice responded to acute pain, but interestingly, were less responsive to inflammatory pain
than their counterparts.