ASIC3 in the cerebrospinal fluid-contacting nucleus of brain parenchyma contributes to inflammatory pain
Antinociceptive action of 4-methyl-5-trifluoromethyl-5-hydroxy-4,5-dihydro-1H-pyrazoie methyl ester in models of inflammatory pain
8 have been implicated in inflammatory pain
, for instance.
Nervous system areas explored in these studies included spinal cord (Coderre & Melzack, 1992), periaqueductal gray substance (PAG) (Vaccarino, Clemmons, Mader, & Magnusson, 1997) and thalamus (Eaton & Salt, 1990) and concluded that NMDA receptor agonism generates an increase in the inflammatory pain
(CFA, Carrageenan, Formalin, etc)
The scientists performed acupuncture on mice suffering chronic inflammatory pain
in one paw.
14) LLLT was shown to reduce hyperalgesia and edema associated with neuropathic pain as well as acute and chronic inflammatory pain
in rats, presumably through upregulation of the endogenous opioid system.
arises in response to tissue injury and the resulting inflammatory process.
6) Like other anti-epileptic drugs, gabapentin has been shown to be effective in the treatment of neuropathic and inflammatory pain
after surgical operations.
On the basis of preclinical evaluation in animal models of human conditions, one might expect a Delta agonist to show effect in inflammatory pain
, among other pain conditions.
Xanodyne has several drugs in late-stage development, including Zipsor, a treatment for mild to moderate inflammatory pain
such as arthritis pain.
The other newly identified lead compound is the second from a program in inflammatory pain