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Against Escherichia coli compound 3 shows intermediate activity at high and low concentrations, while compound 18 shows intermediate and low activities at high and low concentration respectively.
Patients with absent TPMT activity would not receive AZA therapy, while patients with intermediate activity would receive low-dose therapy, and those with normal activity would receive standard weight-based doses.
When truncations are made in NS1, viruses are generated with an intermediate activity, which enables them to replicate in the host and also to induce an interferon response.

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