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Against Escherichia coli compound 3 shows intermediate activity at high and low concentrations, while compound 18 shows intermediate and low activities at high and low concentration respectively.
In the guinea pigs submitted to surgery, the masseter muscle on the right side, after processed by ATPase with alkaline pre-incubation, revealed intermediate activity fibers on the superficial region from the middle portion of the masseter muscle and some with high reactivity spread as mosaic in a highly restricted area, deeper in the muscle after acid preincubation (Figs.
Patients with absent TPMT activity would not receive AZA therapy, while patients with intermediate activity would receive low-dose therapy, and those with normal activity would receive standard weight-based doses.

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