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The deer's unusual fearlessness, its whiteness, and the position of the horn evoke associations of the unicorn, an ancient legendary and biblical figure emblematic of rareness, innate strength, tirelessness, innocence, purity, intractableness, and untamableness (Numbers 23:22, Job 39:9-10).
In Blake's eyes, both groups underestimate the intractableness of natural evils like hunger, death, and Lisbon earthquakes by subsuming them into a rational order.
It is also a story of the intractableness of racism, and its hideous effects throughout all of American society.