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Related to intravascular fluid: interstitial fluid, transcellular fluid
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Hypoalbuminaemia cannot directly cause oedema by fluid extravasation as there is insufficient intravascular fluid to cause any significant expansion of the interstitial space.
That study of nearly 500 patients confirmed that albumin is independently associated with mortality in TBI patients when it is used for intravascular fluid resuscitation in the first 28 days.
The damaged liver fails to produce adequate levels of albumin, which is necessary to maintain the colloid osmotic pressure of intravascular fluid.

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