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Deviation Intrinsic Factor 4.1852 .64457 Income Factor 3.6793 .63792 Independence Factor 3.5253 .82354 Family Security Factor 2.9899 1.19945 TABLE VI: THE ONE WAY MANOVA ANALYSIS TO STUDY SIGNIFICANCE RELATION BETWEEN INDEPENDENT VARIABLE (EDUCATIONAL BACKGROUND) AND DEPENDENT VARIABLES (MOTIVATIONAL FACTORS THAT TRIGGER ENTREPRENEURS) Effect Value F Hypothesis df Pillai's Trace .959 179.991 (b) 11.000 Wilks' Lambda .041 179.991 (b) 11.000 Intercept Hotelling's Trace 23.570 179.991 (b) 11.000 Roy's Largest Root 23.570 179.991 (b) 11.000 Pillai's Trace .394 .864 44.000 Educational Wilks' Lambda .648 .883 44.000 Background Hotelling's Trace .481 .902 44.000 Roy's Largest Root .300 2.376 (c) 11.000 Error df Sig.
We consider that the increased values of B12 vitamin were due to a high titer of intrinsic factor antibody.
PA is macrocytic anemia due to vitamin B12 deficiency as a result of deficiency of intrinsic factor because of the atrophy of gastric mucosa and thus the loss of parietal cells.9 Varying incidence rates of PA have been reported.1011
This can arise from a number of factors which include: (i) decreased synthesis of intrinsic factor (IF) due to the atrophy of gastric mucosa that can occur with ageing; (ii) interaction with drugs, such as antacids, which reduce secretion of gastric acid needed to release B12 from its binding to proteins in the food matrix; and (iii) surgical procedures, such as gastrectomy or resection of the terminal ileum, which can result in reduced absorption due to loss of secretion of IF or to removal of IF receptors, respectively.
Surgical procedures of the gastrointestinal tract such as surgery to remove all or part of the stomach often result in a loss of cells that secrete stomach acid and intrinsic factor (7, 17, 18).
Pernicious anemia is the most common cause of vitamin [B.sub.12] deficiency.[3,10] This problem is thought to be an autoimmune phenomenon involving the formation of antibodies against gastric parietal cells and intrinsic factor. Achlorhydria or decreased stomach acid results from atrophy of parietal cells, and there is decreased absorption of vitamin [B.sub.12] due to decreased amounts of intrinsic factor and a nonacidic medium.[11] Diagnostic criteria for pernicious anemia may include low or borderline vitamin [B.sub.12] levels, the appearance of antiparietal cell or antiintrinsic factor antibodies in the blood, macrocytic anemia, hypersegmented neutrophils, and a positive result on the first part of the classic Schilling test.
Cobalamin is then transferred to intrinsic factor by means of pancreatic enzymes.
The word pernicious means "ruinous, injurious, hurtful." It also can mean "deadly," as in "a pernicious disease." Medical dictionaries define pernicious anemia as "a severe anemia caused by the failure of the gastric mucosa to secrete the intrinsic factor necessary for the absorption of vitamin [B.sub.12]."
The word pernicious, as defined in the dictionary, means "causing insidious harm or ruin; ruinous; injurious; hurtful." The dictionary also defines it as "deadly; fatal: a pernicious disease." Pernicious anemia has its own definition: "A severe anemia caused by the diminution or absence of stomach acid secretion, with consequent failure of the gastric mucosa to secrete the intrinsic factor necessary for the absorption of vitamin [B.sub.12], characterized by a great reduction in the number of red blood cells and an increase in their size."
Teacher's influencing power over the lecture room setting is also intrinsic factor (Lee, et al, 1991).The others essential factors are the work nature, individual recognition and growth opportunities and work freedom.
Such antibodies are present in up to 70% of patients with pernicious anemia; these antibodies may interfere with automated laboratory assays for serum vitamin B12, which utilize a method based on the competitive binding of serum vitamin B12 to reagent intrinsic factor. Manufacturers of automated vitamin B12 assays recommend that patients be tested for intrinsic factor antibodies if test results for serum vitamin B12 conflict with the clinical diagnosis.
The consistent gender ratio suggests that there is some intrinsic factor" that's behind the female advantage in heart disease.