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Additionally, insulin like growth factor-2, which stimulates angiogenesis, is upregulated in proliferating but not involuting blood vessels.
In contrast, the angiogenesis inhibitor metallo proteinase -1 and genes induced by interferon were found to be increased in involuting hemangiomas.
There is a further differentiation of congenital haemangiomas into rapidly involuting congenital haemangiomas (RICH) and non-involuting congenital haemangiomas (NICH).