We believe companies are recognizing the experience we bring to the table and that working with Icagen could improve the efficiency and quality of their ion channel
and transporter small molecule pipelines.
That's highly valuable for an evidence-based approach in drug discovery, and can greatly enhance the way ion channel
drug discovery works".
However, the same cells that lacked the CFTR chloride ion channel
, mimicking the condition in human CF, expressed another, different chloride ion channel
that could be activated by elevating intracellular calcium by the same neurotransmitters.
Waxman's research has shown even more potent ramifications for the role of ion channel
dysfunction in MS, by demonstrating a strong association between sodium channel abnormalities and nerve fiber damage in mice with the MS-like disorder EAE.
With the optical switch in place, researchers could use focused light signals to open ion channels
in specific areas of brain tissue, a potentially powerful technique for determining how neuronal networks function, Isacoff says.
The company's IonFlux system for ion channel
screening is used by leading biopharma and academic institutions for basic research, high throughput screening, and safety testing.
Currently Available Ion Channel
Modulating Drugs in the Market II-2
About ChanTest - The Ion Channel
Expert ChanTest's mission is to serve the drug discovery and development needs of customers worldwide with high-value solutions for ion channel
and GPCR biology.
Fluxion Biosciences today announced that it has signed a distribution agreement for EMD Millipore's PrecisION[R] range of ion channel
today announced its acquisition of assets related to the ion channel
biology platform from Pfizer Inc.
Contributors identified only by name discuss the voltage-gated ion channel
superfamily; state-dependent drug interactions with ion channels
; assay technologies; calcium, sodium, and potassium channels; and genetic and acquired channelopathies.
In 1998, MacKinnon became the first scientist to determine the three-dimensional structure of an ion channel