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However, there is also opposing evidence that the presence of HFE mutation does not cause iron overload in BTT 16.
Iron overload is rare in patients homozygous for the H63D mutation.
This study was done to find out the frequency of iron overload complications like short stature, hypothyroidism, hypoparathyroidism, cardiac dysfunction and diabetes mellitus in beta thalassemia major patients on chelation therapy in our set up where data is scarce.
In clinical trials of patients with transfusional iron overload, the most frequently occurring (greater than 5%) adverse reactions for deferasirox were diarrhea, vomiting, nausea, abdominal pain, skin rashes, and increases in serum creatinine.
The aim of this study is to investigate the effect of iron overload on hematological profile in vivo applying the iron-induced animal model.
People with HH are encouraged to donate whole blood regularly to prevent iron overload. They should also consider reducing intake of foods that increase absorption of iron, eg vitamin C/citrus fruits and red meat, (3,5) and increasing those that inhibit absorption, such as tea and coffee.
Moreover, addressing the psychosocial problems such as attitudes and beliefs about thalassemia, lack of perception of severity of iron overload and expectations from treatment are other important areas to approach thalassemia and iron overload in a holistic manner.
The relationship between iron overload, clinical symptoms, and age in 410 patients with genetic hemochromatosis.
Relationship between hepatitis C virus infection and iron overload. Chin Med J 2017;130:866-71.
(4) However, when the degree of iron overload is beyond the storage capacity, it becomes freely bioavailable and toxic to different tissues and organs through the formation of free radicals.
The iron metabolism is regulated by many factors such as hepcidin, which is peptide hormone that affects iron absorption in small intestine and systemic iron regulation [3]; transferrin (Tf) that bind iron at physiological iron concentrations and nontransferrin bound iron (NTBI) in iron overload concentrations [4]; serum ferritin (SF) and Hemosiderin that reflect the total body iron stores and act as indicative of iron overload [1].
There are four main pathophysiological mechanisms involved in iron overload: increased absorption of dietary iron in the upper intestine, decreased expression of iron regulatory hormone hepcidin, altered function of HFE, and iron-elicited tissue injury with fibrogenesis [2].