Together, these natural extracts help combat immune senescence by several complementary mechanisms that include enhancing activity of natural killer cells
and T cells.
Lutgendorf, "Reciprocal age related change in natural killer cell
receptors for MHC class I," Mechanisms of Ageing and Development, vol.
Mancusi et al., "Clinical impact of natural killer cell
reconstitution after allogeneic hematopoietic transplantation," Seminars in Immunopathology, vol.
Kwong, "Consistent Patterns of Allelic Loss in Natural Killer Cell
Lymphoma," The American Journal of Pathology, vol.
Natural killer cell
activation enhances immune pathology and promotes chronic infection by limiting [CD8.sup.+] T-cell immunity.
Niiro et al., "Interaction between Toll-like receptors and natural killer cells
in the destruction of bile ducts in primary biliary cirrhosis," Hepatology, vol.
Weinhold et al., "Crucial role of DNA methylation in determination of clonally distributed killer cell
Ig-like receptor expression patterns in NK cells," Journal of Immunology, vol.
Suppression of natural killer cell
cytotoxicity in postpartum women.
What is a natural killer cell
? Nat Immunol 2002; 3: 6-8.
Evans and his associates found that resolution of major depression was associated with increased natural killer cell
activity in HIV-seropositive women (Am.
The small differences observed in the number of CD8+-T lymphocytes and natural killer cells
are only of questionable physiological relevance.
Also see Evans 2002 (3): "Our findings provide the first evidence that depression may alter the function of killer lymphocytes in HIV-infected women and suggest that depression may decrease natural killer cell
activity and lead to an increase in activated CD8 T lymphocytes and viral load" (quote from the abstract).