Together, these natural extracts help combat immune senescence by several complementary mechanisms that include enhancing activity of natural
killer cells and T cells.
Lutgendorf, "Reciprocal age related change in natural
killer cell receptors for MHC class I," Mechanisms of Ageing and Development, vol.
Mancusi et al., "Clinical impact of natural
killer cell reconstitution after allogeneic hematopoietic transplantation," Seminars in Immunopathology, vol.
Kwong, "Consistent Patterns of Allelic Loss in Natural
Killer Cell Lymphoma," The American Journal of Pathology, vol.
Natural
killer cell activation enhances immune pathology and promotes chronic infection by limiting [CD8.sup.+] T-cell immunity.
Niiro et al., "Interaction between Toll-like receptors and natural
killer cells in the destruction of bile ducts in primary biliary cirrhosis," Hepatology, vol.
Weinhold et al., "Crucial role of DNA methylation in determination of clonally distributed
killer cell Ig-like receptor expression patterns in NK cells," Journal of Immunology, vol.
Suppression of natural
killer cell cytotoxicity in postpartum women.
Evans and his associates found that resolution of major depression was associated with increased natural
killer cell activity in HIV-seropositive women (Am.
The small differences observed in the number of CD8+-T lymphocytes and natural
killer cells are only of questionable physiological relevance.
Also see Evans 2002 (3): "Our findings provide the first evidence that depression may alter the function of killer lymphocytes in HIV-infected women and suggest that depression may decrease natural
killer cell activity and lead to an increase in activated CD8 T lymphocytes and viral load" (quote from the abstract).