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Compared with the controls, the subjects with rheumatoid arthritis had 17 percent less lean body mass on average, says Roubenoff.
The DEXA scans revealed significant improvements in lean body mass and mineral content in patients who received teduglutide compared to those who received placebo.
Single doses of ACE-031 at 1 mg/kg and 3 mg/kg produced dose-dependent increases in lean body mass measured by dual energy X-ray absorptiometry (DXA) as early as day 15 that were sustained through day 57
In ROMANA 1 and ROMANA 2, anamorelin increased, in respect to placebo, body weight, lean body mass, improved patients' symptoms and concerns related to anorexia/cachexia and was generally well tolerated.
Also, subjects experienced a significant increase in lean body mass and a significant decrease in fat mass on the trunk (Chin.
Obesity has been associated with reductions in growth hormone output and treatment of elderly individuals with growth hormone replacement results in increases in lean body mass and decreases in fat mass.
In ROMANA 1, a pivotal Phase III study, anamorelin was shown to increase lean body mass and body weight, reduce fatigue and improve health-related quality of life in patients with advanced NSCLC cachexia.
Reports that rhGH augments lean body mass and reduces body fat in aged individuals increased use of rhGH to delay aging effects.
Hinton claimed that people who primarily performed non weight-bearing activities would benefit from resistance training that increases lean body mass.
These losses were experienced without any loss of lean body mass.
The largest study so far, of 52 men, 70 and older, in 1996, found that after six months the subjects had an increase in lean body mass and a decrease in fat, but there was no improvement in strength, endurance or mental ability.
8 percent increase in lean body mass (which includes muscle), a 14.