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Related to levofloxacin: ciprofloxacin, Azithromycin
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A methyl group in position 5 as in sparfloxacin prolongs the QT by 14 milliseconds; an amino group in this position, as in grepafloxacin, prolongs the QT by 11 milliseconds; whereas a hydrogen molecule in this position is associated with a QTc prolongation of less than 2 milliseconds for ciprofloxacin, 3 milliseconds for gatifloxacin, and 5 to 6 milliseconds for gemifloxacin, moxifloxacin, and levofloxacin.
The combination of usnic acid with clyndamicin, erythromycin, levofloxacin, oxacillin and gentamicin, is highly synergic only in the last two cases, and, on the contrary, the combination with levofloxacin is not advantageous.
A new study comparing a 300-mg daily dose of cethromycin with levofloxacin therapy is warranted, said Dr.
As with levofloxacin and ciprofloxacin, children and pregnant or lactating women should avoid using gatifloxacin due to articular damage that may occur with these agents (1, 5, 6).
In a retrospective study, the use of levofloxacin (Levaquin[R]), combined with antacids containing aluminum, zinc, magnesium, iron, or calcium, was examined in more than 3,000 hospitalized patients.
By location, ETEC resistance to levofloxacin was far greater in India than in Latin America (41% vs.
GBS CNR0717, a capsular serotype IV strain, was suspected to have reduced susceptibility to FQs because no inhibition zone was observed around disks containing norfloxacin and pefloxacin disks, and reduced diameters were observed around disks containing ciprofloxacin and levofloxacin.
We report a case of torsades de pointes that developed when amiodarone, a class III antiarrhythmic, was added to a drug regimen that included the fluoroquinolone levofloxacin.
Clarithromycin, metronidazole, and levofloxacin resistances were all high among untreated patients, suggesting that they all should be avoided as components of empiric triple therapy [consisting of a] proton pump inhibitor, amoxicillin, plus a third antibiotic," said the researchers.
The MICs of levofloxacin, ciprofloxacin, moxifloxacin, gatifloxacin, and gemifloxacin of the levofloxacin-resistant isolates identified by broth microdilution were further determined by Etest (bioMerieux, Marcy l'Etoile, France).
In this study we demonstrate that curcumin is able to inhibit the SOS response in Escherichia coli induced by levofloxacin.
Azithromycin (Zithromax[R]) and levofloxacin (Levaquin[R]), both antibiotics, are associated with an increased risk of cardiac arrhythmias (irregular heartbeats) and death, according to an analysis of data from the Department of Veteran Affairs.