References in periodicals archive ?
The addition of serum free light chains (sFLC) and IFE increases detection of MM to >99% and is consistent with the International Myeloma Working Group recommended guidelines.
Systemic light chain deposition disease presenting as multiple pulmonary nodules: a case report and review of the literature.
Serum free light chain analysis in the diagnosis and management of multiple myeloma and related conditions.
Recently, the serum levels of kappa and lambda free light chains (FLC) of immunoglobulin have been used to diagnose and monitor plasma cell dyscrasias and have been proposed as biomarkers of immune stimulation and inflammation.
Formation of assemblies on cell membranes by secreted proteins: molecular studies of free A light chain aggregates found on the surface of myeloma cells," The Biochemical Journal, vol.
J Tetanus toxin light chain holds the HEXXH zinc protease consensus motif and acts as a toxic part of toxin and zinc-dependent endopeptidase(5,6).
The evolving use of serum free light chain assays in hematology.
31) On the other hand, the ATPase and motility of smooth muscle and nonmuscle myosin II are activated by phosphorylation through myosin light chain kinase activated by [Ca.
Understanding Serum Free Light Chain Assays [online document].
Based on the morphology on routine staining, the non-Congophilic nature of the deposits and the strong PAS staining of sinusoidal walls; diagnosis of Light Chain Deposition Disease (LCDD) was suggested.
Multiple myeloma with multinucleated plasma cells is a rare morphological variant, which usually presents with light chain expression, and is characterized by an aggressive course and resistance to conventional chemotherapy (1), (2).
In a study including juvenile idiopathic arthtiris (JIA) patients, abnormalities in the peripheral B cell pool, namely kappa light chain repertoire were observed and the possibility of disturbance in B cell tolerance by multiple pathogenic mechanisms in JIA was highlighted.