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Lead author Julianne Holt-Lunstad, professor of psychology and neuroscience at Brigham Young University in the US, described a loneliness epidemic with a huge public health impact.
But while awareness has grown about loneliness among older people, far less attention is given to how it affects young people.
According to the Campaign To End Loneliness, more than half the country's 75-year-olds currently live alone.
A strategy to deal with loneliness and isolation - "one of the most significant issues facing people in Wales" - will be published for consultation this year.
The draft plan, now open for consultation, will look at the causes of social isolation and loneliness and how they can be addressed.
The Commission was set up following Jo's tragic death by her husband, Brendan, to continue the work Jo began in Parliament to tackle loneliness and it has been a privilege to be able to support its work in Parliament over the past 18 months.
Buddies are being encouraged to speak to their neighbours more often to help reduce the impact of loneliness and social isolation.
The consultation will run until April 30 and contribute to a new strategy to tackle loneliness and isolation.
The Commission on Loneliness was first set up by Ms Cox, who was killed before the EU referendum.
According to CNN, the Jo Cox Commission on Loneliness was created as a response to the MP's own experience of isolation.
We should all do everything we can to see that, in Jo's memory, we bring an end to the acceptance of loneliness for good," British Prime Minister Theresa May said in a statement.
Tracey Crouch, the Minister for Sport and Civil Society, will fill the newly-created role of ministerial lead on loneliness to head up the Government's work to tackle a problem that is believed to affect nine million people in the UK.