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Related to loop of Henle: Distal tubule, Collecting duct
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04 ml (Figure 7) showed arrangement of tubules with marked alterations in the loop of henle and reduction in the tubular cells around glomeruli.
Genetic diseases associated with this clinical phenotype are characterized by impaired transport function of either ascending loop of Henle (LOH) tubular cells (Bartter syndrome) or thiazide-sensitive tubular cells in the distal nephron (Gitelman syndrome).
42), (45-46) It has been proposed that plaque formation in the thin descending loop of Henle occurs because of an increase in interstitial calcium and phosphate concentration, as well as an increase in renal papillary osmolality as a result of water reabsorption in this nephron segment, but clinical evidence for this hypothesis is lacking.
Chlorothiazide is a sulfonamide loop diuretic that acts on the distal tubule and thick ascending limb of the loop of Henle.
In the thick ascending limb of the loop of Henle, the chloride pump promotes passive reabsorption of sodium ion and actively reabsorbs chlorine ion.
Evidence for a concentration gradient favoring outward movement of sodium from the thin loop of Henle.
Since 30-50% of filtered sodium is reabsorbed in the loop of Henle using this transport system, frusemide has high natriuretic properties.
Merc was still widely used, even though the amazing new loop of Henle diuretics were rapidly taking over the field.
Also, as the filtrate descends through the loop of Henle into the hyperosmotic medulla, water is reabsorbed, but what prevents a flow reversal as the filtrate turns and ascends toward the renal cortex?