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Microscopically, the lesion often shows basal vacuolization, lymphocytic infiltration along the dermal-epidermal junction, and apoptotic keratinocytes.
Full-thickness biopsies taken during laparoscopy in these patients have shown lymphocytic infiltration of the myenteric plexus.
The researchers reported that from biopsy samples of 10 patients analyzed before and after treatment, an increase in the degree of lymphocytic infiltration was noted in 5 patients.
A bone marrow biopsy is seldom required for the diagnosis; however, patterns and degree of lymphocytic infiltration has prognostic significance.
Confirmation of the diagnosis is made by histopathologic evaluation of a labial minor salivary gland biopsy that shows lymphocytic infiltration.
26,34) Other histologic features that may be present include intraepithelial lymphocytes, type II pneumocyte hyperplasia, focal lymphocytic infiltration of vessel walls, foci of organizing pneumonia, loose nonnecrotizing granulomas, and occasional isolated giant cells.
The arteritis was similar to the autoimmune vascular lesions accompanying AD in mink with adventitial lymphocytic infiltration (4).

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