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Caption: FIGURE 3: Pathology of lung biopsy specimen from a patient with lymphoid interstitial pneumonia. (a) Low power view showing peribronchiolar and interstitial lymphocytic follicular aggregates alongside dilated cystic air spaces (magnification x40).
Primary pulmonary lymphoma: a re-appraisal of its histogenesis and its relationship to pseudolymphoma and lymphoid interstitial pneumonia. Histopathology 1988;13:1-17.
Autoimmune diseases, including lymphoid interstitial pneumonia and autoimmune endocrinopathies such as thyroiditis, occur in approximately 22% of patients.
(1) The updated classification described 2 rare IIPs: lymphoid interstitial pneumonia (LIP) and pleuroparenchymal fibroelastosis (PPFE).
(7) The idiopathic pneumonias such as desquamative interstitial pneumonia (DIP), acute interstitial pneumonia (AIP), nonspecific interstitial pneumonia (NSIP), and lymphoid interstitial pneumonia (LIP) may have features consistent with the peripheral reticular pattern.
The morphologic domain consists of 3 categories thusly divided: ILD patterns observed on HRCT characterized by nonspecific interstitial pneumonia (NSIP; Figure 1, A and B), organizing pneumonia (OP; Figure 2, A), lymphoid interstitial pneumonia (Figure 3, A and B), or NSIP with OP; patterns of ILD or changes suggestive of autoimmunity in pulmonary surgical biopsy, that is, NSIP (Figure 1, C and D), OP (Figure 2, B), NSIP with OP, lymphoid interstitial pneumonia (Figure 3, C and D), and interstitial lymphoid aggregates with germinal centers and diffuse lymphoplasmacytic infiltration (Figure 4); and evidence of involvement of multiple thoracic compartments associated with ILD diagnosed by imaging exams, histopathologic findings, right heart catheterization, or pulmonary function tests.