major misfortune

See: calamity
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DAVE POWELL says a slice of major misfortune has cost Prescot Cables a place in the next round of the FA Cup.
We should look at the matter from the EU's side as well, and many observers think that Turkey's not being an EU member is a major misfortune for the EU.
I have heard stories of colleagues on the same trade union programme as me having to go into major debt because they or somebody in their family has had the major misfortune to get ill.
He warned: "A massive [Turkish] retaliation [to PKK attacks] would be a major misfortune for Turkey, Iraq and the United States.
It was Douglas' next major misfortune when he was injured in Scotland's crucial away match in Milan in a World Cup qualifier that ushered Gordon into the team as a 38th-minute substitute.
Diamonds skipper James Grieves fell when leading the race ( his second piece of major misfortune in the match as an engine failure robbed him of probable victory in heat four ( allowing Glasgow captain Shane Parker, taking a tactical ride, the luxury of bagging six points for the win.
If we suffer some major misfortune - illness, job loss, accident, etc.
BEFORE you appeared in Chicago, you had the major misfortune of appearing alongside Johnny Vaughan (on Channel 4's The Big Breakfast).
There were no missed chances, regrets, dreadful traumas and none of the kind of major misfortunes that can blight a lifetime.
Interestingly, for Paracelsus the apocalyptic winding down of the cosmos was "stamped also into the essence of the human constitution" (211) so that human sin and illness affected the stars themselves, which returned the favor, resulting in major misfortunes such as syphilis--a disease that Paracelsus sought energetically to cure.
The AICPA Benevolent Fund helps members and their families when they face financial difficulty caused by serious illness, accident, death or other major misfortunes.