Recently, BPA and other xenoestrogens have been shown to mediate
[Ca.sup.2+] influx and prolactin release in GH3/B6 pituitary tumor cells at low concentrations (Wozniak et al.
Activation of EGF receptors mediates
pulmonary vasoconstriction induced by residual oil fly ash.
Often, a bacterium must adhere very tightly to the cells and mediate
its effects extracellularly, or it must find a way to invade the host's cells and survive intracellularly.
We established a cell model with which to screen the rapid nongenomic activities of estrogenic compounds using cells naturally expressing high levels of a membrane form of ER-[alpha] thought to mediate
these nongenomic actions.
The Environmental Policy and Conflict Resolution Act states that any federal agency may use USIECR to assess or mediate
any conflict related to the environment, public lands, or natural resources.
Unlike ligands of nuclear receptors, which bind in nanomolar concentrations, the endogenous PPAR ligands, fatty acids, mediate
their effects at micromolar concentrations (Willson et al.
These data suggest that ERK-2 is an intracellular target of oxidative and bacterial stress in amphibians that mediates
, at least in part, the cytotoxic response to hydrogen peroxide or lipopolysaccharide.
estradiol-induced inflammation in the lateral prostate of Wistar rats.
AhR is a ligand-activated transcription factor that mediates
the toxic actions of environmental contaminants such as 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD).
PPAR[Alpha] mRNA and the corresponding functional protein (i.e., the protein that mediates
transcriptional activation through PPRE) are also expressed in guinea pig liver, but at much lower levels than in mice (46,47).
These findings indicate that [GH.sub.4][C.sub.1] cells express purinogenic receptors with selectivity consistent with the P2X7 subtype and that this receptor pathway mediates
the induction of the c-fos luciferase reporter gene by ATP and the putative Pfiesteria toxin.