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Duplication of normal genes [right arrow] ultrafast metaboliser.
As well as age-related changes in metabolic processes, there are segments of the population who may unknowingly be genetically poor metabolisers for particular drug metabolism pathways, with the result that drug dosage should be reduced to avoid adverse effects.
The potential study participants were genotyped by PAREXEL to identify nearly 400 poor metabolisers of Cytochrome P450 2D6 (CYP2D6), an enzyme involved in the metabolism of drugs.