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Two normal genes [right arrow] extensive metaboliser.
As well as age-related changes in metabolic processes, there are segments of the population who may unknowingly be genetically poor metabolisers for particular drug metabolism pathways, with the result that drug dosage should be reduced to avoid adverse effects.
Metabolic disposition of proguanil in extensive and poor metabolisers of Smephenytoin 4'-hydroxylation recruited from an Indonesian population.