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Related to metalloproteinase inhibitor: metalloprotease inhibitor
See: deterrent
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BB-3644 is a second-generation matrix metalloproteinase inhibitor.
Marimastat, a matrix metalloproteinase inhibitor, is in Phase III development for the treatment of cancer; BB-3644, a follow-on to marimastat, is in Phase I development for cancer; BB-10153 has completed Phase I development for cardiovascular disease; BB-2827, a collagenase inhibitor for inflammation, is in Phase I development; and E21R, a modified GM-CSF, has completed Phase I development.
As MMP-9 and MMP-2 can degrade Type IV, Type VII collagen and laminin, doxycycline and steroids, both metalloproteinase inhibitors, are commonly used in the treatment of RCES.
Overall, Linder recommended using a formula that contains broad-spectrum UV protection, matrix metalloproteinase inhibitors (MMPi), antioxidants, retinoids, ascorbic acid and peptides to improve collagen and matrix protection and production.
Matrix metalloproteinase inhibitors as prospective agents for the prevention and treatment of cardiovascular and neoplastic diseases [Electronic version].
They cover carbonic anhydrase inhibitors and activators, matrix metalloproteinase inhibitors, bacterial zinc protease inhibitors, and other enzymes containing zinc.
Medications on the horizon like pioglitazones and matrix metalloproteinase inhibitors hold great promise.
General definitions: Androgen Antagonists, Cell-cycle inhibitors, Cell death pathway interactions, Cytokine effects, DNA intercalators, Cellular metabolism disruptions, Hormone agonists, Immunostimulations, MDR, Metalloproteinase inhibitors, Peptide hormones, Protein Kinase Inhibitors, Retinoids and Tumor Antigens.
However, the presence of all of their histologic parameters must be correlated with other key factors that modulate fibrogenesis, such as interaction of stellate cells, role of metalloproteinase inhibitors, and changes in collagen synthesis.
Additionally, the Company's MultiStat([R]) compounds have been shown to be 1,000 times more potent than the natural matrix metalloproteinase inhibitors that are present in human blood and some plant extracts.

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