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Collectively, these results suggest that rutin protects vascular barrier integrity by inhibiting hyperpermeability, expression of CAMs, adhesion and migration of leukocytes, thereby endorsing its usefulness as a therapy for vascular inflammatory diseases.
Greater migration of leukocytes in carrageenin injected tilapia was in agreement with the inflammatory response found by Martins et al.
It is an important constituent in the intercellular unions between the endothelial cells and a key element in the transendothelial migration of leukocytes during the inflammatory process (Albelda et al.

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