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Six patients responded to the combination regimen, three of whom achieved a complete response (CR) and three a minor response (MR).
Minor responses in 6 patients showed tumor regression between 10% and 30%
Minor responses in 4 patients showing tumor regression greater than 10% but less than 30%
Data from a Phase 1 human clinical trial have demonstrated that treatment with ARQ 197 was well tolerated over extended dosing periods, with 60 percent of evaluable patients experiencing partial responses, minor responses or stable disease.
In 14 of the 31 patients (45%), there is a clinically beneficial response including one partial response (PR), four minor responses (MR), and nine with stable disease (SD).