In the study, the scientists used mouse models to demonstrate that Stat3 promotes
mitochondrial respiration.
Co-regulation of
mitochondrial respiration by proline dehydrogenase/oxidase and succinate.
In a subgroup of 4 participants, venous blood samples were taken before and after the training intervention to analyze
mitochondrial respiration of PBMCs.
Mitochondrial oxygen consumption and respiratory control ratios for compounds exhibiting effects similar to inhibitors of
mitochondrial respiration. Oxygen consumption was measured using the Clark-type oxygen electrode after the isolated rat liver mitochondria were incubated with various concentrations of (A and B) antimycin A, (C and D) rotenone, (E and F) picoxystrobin, (G and H pinacyanol, and (I and J) C.I.
In order to investigate the effect of CoQ10 on the
mitochondrial respiration parameters in epidermis, we applied an ubiquinol formulation (QuinoMit Q10 fluid; MSE Pharmazeutika GmbH, Bad Homburg, Germany).
Consistent with the previous study [72], inhibition of glucose metabolism increased
mitochondrial respiration concomitant with ROS-dependent increases in lifespan, stress resistance, and antioxidant enzyme activity.
It is also important to note that excessive production of N[O.sup.*] can cause inhibition of
mitochondrial respiration, by irreversibly binding to complex I [74] or reversibly binding to complex IV [75].
The role of nonshivering or adaptive thermogenesis (the generation of heat through uncoupling of
mitochondrial respiration) in total energy expenditure is now being appreciated [5], with obese individuals demonstrating a reduced adaptive thermogenic capacity [6].
Scheff, "Age-related changes in
mitochondrial respiration and oxidative damage in the cerebral cortex of the Fischer 344 rat," Mechanisms of Ageing and Development, vol.
Mice genetically lacking miR-378-3p exhibit enhanced mitochondrial fatty acid metabolism and elevated oxidative capacity of insulin-target tissues [92], proving its key role in
mitochondrial respiration.
At the Department of Physiology of the Faculty of Medicine in Novi Sad we are currently measuring normal
mitochondrial respiration capacity in the rat heart and Guinea pig heart following the in situ method (Figure 2).
Nitrite and Nitrite-mediated NO formation have multiple beneficial effects, including dilation of blood vessels, reduction in hemodynamic perturbations during exercise in the failing heart, and improvements in skeletal muscle bioenergetics and
mitochondrial respiration, resulting in improved efficiency of oxygen utilisation during submaximal exercise.
