This is the extremely rare malignant counterpart to mixed tumor
. It can either take the form of carcinoma growing out of a benign mixed tumor
precursor or have the overall appearance of a mixed tumor
but with the addition of infiltrative growth, marked nuclear atypia, tumor necrosis, and/or brisk/atypical mitoses.
E) Benign mixed tumor
. F) Benign mixed tumor
(reactivity in proteinaceous matter).
 CT, MRI, biopsy mixed tumor
Bettaieb Ultrasonography NM Excision et al.
Carcinomatous change in the cranial metastasizing mixed tumor
of the salivary gland.
(9) Mixed tumor
of the minor salivary glands affects mostly patients in their fourth to sixth decades, with a predominance of females.
Pleomorphic adenomas come in the differential diagnosis of chondroid syringomas but in contrast to those syringomas arise from sweat glands.8 Based on the histopathological differences chondroid syringomas have eccrine and apocrine variants.9 Mills reported that mixed tumors
are monoclonal neoplasms with replicating cells that can differentiate towards mesenchymal or epithelial components and this accounts for the histological differences of the mixed tumor
of the skin.10 The treatment of choice for chondroid syringoma is wide surgical excision.11 Because of the lobulated nature of the tumor, the margins of the normal tissue should also be included with the excision to ensure complete removal of the tumor.11
It usually occurs in middle aged and elderly patients.1 It was described by Billorth in 1859 for a group of tumours of the salivary gland that contained varying amounts of mucoid and cartilaginous material.2 Virchow and Minssen at referred to them as mixed tumors
with both epithelial and mesenchymal origins.3 We present a rare case of chondroid syringoma on the face of a young male.
The pathologist diagnosed the specimen as a benign mixed tumor
. The specimen was sent to a second pathologist and also included immunohistochemistry (IHC) for a confirmation of the diagnosis.
average 1 SC 6 0 (0%) 0 0 0 2 CMT 1 0 (0%) 0 0 0 3 SC 3 0 (0%) 0 0 0 4 CC 29 22 (76%) 41 1.41 1.52 5 CC 19 12 (63%) 31 1.63 2 6 CC 5 1 (20%) 1 0.20 0.20 7 CC 7 7 (100%) 16 2.29 3.14 8 SC 4 3 (75%) 4 1 1 total 74 45 (61%) 93 1.26 1.47 HT: histological type, No: number of metaphases, metaph.: metaphases showing breaks (B) and/or gaps (G), chrom.: average number of chromosomes showing B and/or G, average: average number of B and/or G per metaphase, SC: simple carcinoma, CTM: carcinoma in mixed tumor
, CC: complex carcinoma.
Malignant mixed tumor
(MMT) is an exceedingly rare cutaneous adnexal carcinoma with a significant risk for aggressive behavior and a propensity for metastasis.
The reading of the slides was accomplished with a light microscope (ZEISS--I Model AXIO Imager A1) and enabled the lesions to be classified as benign (adenoma and benign mixed tumor
) or malignant (simple and complex carcinoma).
They are commonly found alone or in association with one of the numerous other mixed tumors
or dental abnormalities.