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Overall, the vast majority of patients at our cancer center were treated with multimodality therapy, which represents the standard of care as outlined in the NCCN practice guidelines.
18) indicated, in combination with granulocyte-macrophage colony-stimulating factor (GM-CSF), interleukin-2 (IL-2), and 13-cis-retinoic acid (RA), for the treatment of pediatric patients with high-risk neuroblastoma who achieve at least a partial response to prior first-line multiagent, multimodality therapy.
In spite of multimodality therapy, the prognosis is still grave, with >95% of patients dead from disease in <9 months.
Overall, these data suggest that the angiographic obliteration rate of DAVFs treated with multimodality therapy that included radiosurgery is >40%, with higher rates of subtotal obliteration and low morbidity.
These observations have led to the development of multimodality therapy for the treatment of patients with advanced thymoma.
Wessalowski stated, "By multimodality therapy with regional hyperthermia, local tumor control rate and long-term survival can be improved in children with high-risk tumors with dismal prognoses.

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