Once they were able to isolate skeletal
muscle cells using the newly identified surface markers, the research team matured those cells in the lab to create dystrophin-producing muscle fibers.
The development of atherosclerotic plaques is a slow and gradual process, pathologically characterized by the proliferation and migration of vascular smooth
muscle cells [1-10].
The cytoskeleton of the vertebrate smooth
muscle cell.
In vitro, infected arterial smooth
muscle cells accumulated cholesterol.
However, interrupting the Wnt signal caused myoblasts already on their way to becoming
muscle cells to switch gear and develop into fat.
The symptoms associated with LAM are caused by the excessive growth of the
muscle cells around the airways, and blood and lymph vessels.
Beating heart
muscle cells were formed within 12 days.
The finding, appearing in the April 3 Science, contradicts the belief of many scientists that heart
muscle cells present at death have been around since birth.
Bone marrow not only can differentiate into heart cells but also smooth
muscle cells, connective tissue cells, and other types of cells to reconstitute the entire structure of a tissue," he said.
Previous work in direct reprogramming, jumping straight from a cell type involved in scarring to heart
muscle cells, has a low success rate.
Cao and her colleagues have taken a big step in that direction, showing that a toxic protein destroys
muscle cells inside the patients' arteries.
Unlike other cell types, such as heart cells, neurons and cells found in the gut, previous attempts to efficiently and accurately derive
muscle cells from pre-cursor cells or culture have not been fruitful.
