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The 1/ strain in genotype group 1c has nonsynonymous SNVs at 3 of the 7 loci (K357N in VP2 and V81A and Q169R in VP6) but a VP5-encoding gene apparently derived by reassortment from a virus resembling 4/Lab/ZAF/98/OBP-116, such that the SNVs in the VP5 of this strain were also not considered to be mutationally derived.
In conclusion AMR-MeOAc inhibits mutationally activated K-Ras-ERK and Akt signaling coupled with inhibition of survivin and activation of apoptotic cascade resulting death of pancreatic cancer cells.
Guinness/1322 (Bulgaria), for an example, was mutationally bred from Katya (a hexaploid wheat cultivar from Bulgaria) by 50 Gy [sup.60]Co [gamma]-ray [6].