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In evaluating peripheral nerve function, electrodiagnostic testing examines the integrity of only large myelinated nerve fibers with the fastest conduction velocities.
A sural nerve biopsy disclosed a moderately severe depopulation of myelinated nerve fibers.
Although the rebuilt sheaths were spare compared with the thick myelin sheaths of healthy mice, he says computer simulations by other research teams suggest that even thinly myelinated nerve fibers can conduct electrical impulses almost normally.