Therefore, considering the disease mechanisms of McArdle disease, this type of training may have potential to increase resistance of the muscle fibres to damage during physical activity, decreasing the risk of recurrent myoglobinuria
Dark urine in adult malaria patients has been linked to myoglobinuria
and rhabdomyolysis [10, 16, 17].
Though cases of inflammatory myopathy causing myoglobinuria
and rhabdomyolysis are rare, it is important to have a high index of suspicion to avoid end organ damage.
Pathological causes are hematuria, hemoglobinuria, myoglobinuria
, and porphyrinuria.
Mutations in human Lpinl cause severe myoglobinuria
in childhood (Michot et al., 2010), and those in Lpin2 are associated with an autoinflammatory bone disease known as Majeed syndrome (Herlin et al., 2013).
Tularemia 3-5 days (range General: [up arrow] ESR, (Francisella 1-21 days) leukocytosis, thrombocytopenia, tularensis) transaminitis, myoglobinuria
, [up arrow] CPK.
Figure 1: GPL-[SNP.sub.1000] Gene Groups and SNPs Pathway Clinical Significance # of SNPs DNA Methylation Developmental delays 105 Mental disorders Risk of homocysteinemia Mental Health Mental disorders 53 Drug Metabolism Increased risk of adverse 241 drug reactions Autism Spectrum Genes Developmental delays and 252 disorders Oxalate Metabolism Primary hyperoxaluria 32 Myoglobinuria
Fibromyalgia Autism Vulvodynia Gluten Sensitivity 48 Cholesterol Metabolism Mental disorders 101 Heart disease Increased risk of obesity Acetaminophen Toxicity Increased risk of adverse 72 drug reactions Transporters Liver disease 130 Coronary disease Mental disorders
These conditions usually have a hereditary component and noteworthy features are episodes of acute myalgia with associated myoglobinuria
and accompanying dark-coloured urine.
, malignant hyperthermia, neuroleptic malignant sindrome and serotonin sindrome.
Additional signs may include elevated creatine phosphokinase, myoglobinuria
(rhabdomyolysis), and acute renal failure.
Acute kidney insufficiency (AKI) can occur secondary to myoglobinuria
and to hypovolemia, which occurs as a result of fluid shifts into the affected muscles.