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It is a potent, orally-active opioid narcotic antagonist that does not cross the blood-brain barrier and is not significantly absorbed from the intestine.
Nonspecific therapies include the antihypertensive/central anaigesic clonidine, the narcotic antagonists naloxone and naltrexone, and melatonin.
Other products derived from thebaine include the narcotic antagonists naloxone and naltrexone.