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A phase 1 clinical trial of nerve growth factor gene therapy for Alzheimer disease.
Absence of nerve growth factor and comparison of tyrosine kinase receptor A levels in mature spermatozoa from oligoasthenozoospermic, asthenozoospermic and fertile men.
Neurotrophins, such as nerve growth factor (NGF) and brain derived neurotrophic factor (BDNF), are responsible for the development and maintenance of basal forebrain cholinergic neurons (Thoenen, 1991).
The database currently tags 37,000 individuals working in Nerve Growth Factor.
Using diabetic rats and isolated retinal cells cultured in high glucose, El-Remessy and colleagues found that oral treatment with the drug atorvastatin blocked the formation of free radicals in the retina, which restored proper levels of nerve growth factor and preserved neurons in the retina.
Upon exposure to nerve growth factor (NGF), PC12 cells developed neuritic projections in association with vastly increased TH and ChAT expression accompanying differentiation into the two phenotypes.
The gene added in this study encodes nerve growth factor (NGF), a protein that keeps these cells alive and so facilitates signaling among them.
Neotrofin is a small molecule that crosses the blood-brain barrier, enhances memory and causes the production of neurotrophic factors including nerve growth factor, which are believed to lead to nerve regeneration and sprouting.
Scientist Jon Cooper, from King's College, London, said: "Our findings suggest that nerve growth factor deprivation is responsible for the age related cell loss associated with Alzheimer's disease.
The cells were programmed to produce high amounts of a protein known as nerve growth factor, which nourishes nerve cells and helps them to grow and maintain connections with other brain cells, reported principal investigator Mark Tuszynski, MD of the University of California, San Diego at the American Academy of Neurology annual meeting last month.
Scientists also know that stress reduces the production of a certain type of nerve growth factor found in the hippocampus by as much as 50 percent.