Delayed metabolism of human brain natriuretic peptide reflects resistance to neutral endopeptidase
Nevertheless, as it was still unclear whether reduction of neprilysin expression or activity precedes A[beta] pathology during the course of aging, we thus examined the effect of aging on the expression/ activity of brain neprilyisn using two methods: (i) A biochemical assay to measure neutral endopeptidase
activity in the brain (The advantage of this is that it is more quantitative than the latter, whereas the disadvantage is that the method fails to provide information regarding the local or spatial activity/ expression of neprilysin).
Androgen-induced growth inhibition of androgen receptor expressing androgen-independent prostate cancer cells is mediated by increased levels of neutral endopeptidase
Function of neutral endopeptidase
on the cell membrane of human neutrophils.
Key words: green tea, neutral endopeptidase
, angiotensin-converting enzyme, enzyme induction
The best-studied member of a novel class of drugs known as vasopeptidase inhibitors, omapatrilat inhibits both angiotensin-converting enzyme and neutral endopeptidase
, the enzyme that breaks down vasodilator factors.
BNP is known to be cleared from the circulation by the natriuretic peptide clearance receptor, neutral endopeptidase
cleavage, and the kidney (27).
In addition to elimination by renal excretion and by binding to natriuretic peptide receptor type C (7), natriuretic peptides are also cleared through proteolysis by peptidases, the most closely studied being neutral endopeptidase
(NEP; EC 3.
Relation of ANP and BNP to their N-terminal fragments in fetal circulation: evidence for enhanced neutral endopeptidase
activity and resistance of BNP to neutral endopeptidase
in the fetus.