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To determine the absolute risk of MI among nucleoside analogue users, the investigators incorporated the Framingham predicted 10-year coronary heart disease risk into the main regression model, and determined that the rate of MI was increased by 119% in patients with a moderate 10-year risk and by 222% in patients with a high 10-year risk, relative to those with a low 10-year risk, Dr.
Nucleoside Analogue Reverse Transcriptase Inhibitors Generic Name Initials Trade Name Manufacturer Didanosine (1990) ddl Videx Bristol-Myers Squibb Lamivudine (1995) 3TC Epivir Glaxo Wellcome Stavudine (1994) d4T Zerit Bristol-Myers Squibb Zalcitabine (1992) ddC HIVID Hoffmann-LaRoche Zidovudine (1987) AZT/ZDV Retrovir Glaxo Wellcome Table 2.
Only patients with severe acute HBV infection warrant nucleoside analogue treatment, as more than 95% of immunocompetent patients with acute HBV recover.
Adults: The recommended dosage of SUSTIVA is 600 mg orally, once daily, in combination with a protease inhibitor and/or nucleoside analogue reverse transcriptase inhibitors (NRTIs).
The Company's pipeline includes FV-100, its clinical-stage oral nucleoside analogue in development for the treatment of herpes zoster (shingles), as well as a series of HCV nucleoside polymerase inhibitors and HIV integrase inhibitors.
This trial provides an opportunity to assess the cellular pharmacology of this novel nucleoside analogue, which is an important step toward providing guidance for optimizing dose and schedule for future trials," said Dr.
Judy Chiao, Cyclacel's VP Clinical Development and Regulatory Affairs, said, "CYC682 is a novel nucleoside analogue that acts by a unique mechanism of inhibiting DNA synthesis and triggering cell checkpoint machinery to arrest cell cycle progression.
Chemists and pharmacists here explore some of the techniques used to synthesize nucleoside analogues.
An increase of lactic acid in the blood (lactic acidosis), which can cause death, has been reported in patients taking REYATAZ with other anti-HIV medicines called nucleoside analogues.
Approved March 14, 1996 for use alone or in combination with nucleoside analogues for the treatment of HIV infection in adults.

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