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The second key challenge, he said, is the need for constant exposure to cholinergic neurons that comprise the nucleus basalis of Meynert (NBM) while avoiding exposure to untargeted neuronal populations.
CERE-110 is surgically injected into the nucleus basalis of Meynert (NBM), a brain region where cholinergic nerve cell degeneration occurs in AD.
Although it is possible that both of the diseases may lie on a continuum of a single disease that begins with ADHD manifested in childhood and continues into adulthood as dementia with Lewy bodies "when neuronal loss and gliosis in the substantia nigra, locus coeruleus, and nucleus basalis of Meynert occur," the authors doubted that this hypothesis could be accurate because low dopamine levels in ADHD are not initially associated with Parkinsonlike or DLB symptoms.

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