obtund

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6[micro]g/kg body weight and 1[micro]g/kg body weight diluted in 10 ml saline, given 10 minutes before induction are equally efficacious in obtunding the haemodynamic responses to laryngoscopy and endotracheal intubation.
Intravenous Clonidine, a central [alpha]-2 agonist has become a popular agent for obtunding haemodynamic responses to laryngoscopy and intubation.
19) Our finding are in consistent with the findings of Gamlin et al (29) who have reported effectiveness of ephedrine in obtunding hypotensive effects of propofol when it was mixed with propofol.