of uncertain significance

See: equivocal
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Germane to both of these applications are the selection of genes for analysis that are consistent with the patient's phenotype, the challenges to interpretation of variants and detection of variants of uncertain significance, and the need for access to detailed clinical phenotypic information in order for the laboratory to be able to make a clinical interpretation.
Besides this, increasing the number of analysed genes will increase the number of variants of uncertain significance in clinical testing.
These help to assess and classify the clinical meaning of genetic variants of uncertain significance, which can ultimately provide healthcare providers and patients with a clearer result and help identify treatments.
These guidelines provide a revised and expanded framework for classifying germline sequence variants for inherited Mendelian disorders using 1 of 5 terms that indicate a variant's likelihood to cause disease (pathogenic, likely pathogenic, variant of uncertain significance, likely benign, benign).
The topics include colposcopy, negative for intraepithelial lesion and malignancy, low-grade and high-grade squamous intraepithelial lesions, atypical squamous cells of uncertain significance, adenocarcinoma, and cervical cancer screening and follow-up of limited and abnormal screen results.
In addition we also used reactive smears and smears with atypical squamous cells of uncertain significance (ASCUS).
A variant of uncertain significance means that a genetic change has been identified, but more information is needed to determine if the change can cause health problems or if the change is a normal variation.
The test has expected 3% variant of uncertain significance (VUS) rate for BRCA1/BRCA2 mutations, ensuring a clearer management pathway for ovarian cancer patients, as well as an average two-week lab turnaround time, enabling doctors and patients to make critical treatment decisions.
Hysteroscopy also found one or more "subtle" abnormalities in 13% of the examined women, a category for abnormalities of uncertain significance that included hypervascularization of the uterus (20 women) and mucosal elevation (13 women).
These implements are no longer considered simple gadgets and ordinary appliances of uncertain significance.
A variant that has been identified in a patient but not previously known to cause the disease in question is termed a variant of uncertain significance (VUS).