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The stability of creams, which are generally oil in water emulsions are much more prone to microbial contamination as the continuous aqueous phase is a much more favorable medium for growth than the fatty continuous phase of an ointment base.
However, moisturizers in an ointment base are usually more effective.
Yissum subsequently applied to the UK Patent Office for an SPC for calcitriol either solely for calcitriol or alternatively for a combination of calcitriol with an ointment base.