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Late-season" skim milk, which is primarily available from countries where milking is seasonal and cows are grass fed, is high in orotic acid, a substance known to promote uric acid removal by the kidneys, explained Dr.
Interestingly, late-season skim milk led to a greater increase in FEUA, compared with either ultrafiltered skim milk or early-season skim milk, suggesting that the acute urate-lowering effect of orotic acid may explain these effects.
While the mechanisms have not been confirmed, it has been hypothesized that orotic acid produced during lactic acid fermentation may inhibit cholesterol production in the liver.
The pyrimidines uracil and orotic acid are formed directly from HCN, whereas uracil and cytosine are formed from cyano-acetylene [ILLUSTRATION FOR FIGURE 2 OMITTED](3).
Thus, this enzyme would provide CP not only to the arginine de novo biosynthetic pathway but also to the orotic acid pathway for the de novo biosynthesis of pyrimidine nucleotides.
We purchased the following compounds from Sigma: adenine, adenosine, 2-deoxyadenosine, 2-deoxyguanosine, inosine, 2-deoxyinosine, xanthine, hypoxanthine, orotic acid, uric acid, thymine, uracil, dihydrothymine, dihydrouracil, N-carbamyl-[beta]-aminoisobutyric acid, N-carbamyl-[beta]-alanine, thymidine, uridine, pseudouracil, 5-hydroxymethyluracil, and 2-deoxyuridine.