These findings show the effectiveness of humoral factors starting the maturation of osteoprogenitor cells
2 days after trauma (43).
As a positive point of the study, the application of osteoprogenitor cells
improve bone regeneration temporarily, suggesting that multiple application of these cells could be an efficient therapy for critical bone defects in dogs.
Increased bone formation by intermittent parathyroid hormone administration is due to the stimulation of proliferation and differentiation of osteoprogenitor cells
in bone marrow.
As mentioned earlier, the pathogenesis of ectopic ossification requires a local event that initiates the differentiation of mesenchymal cells into osteoprogenitor cells
He found that an induction cell such as a histiocyte acts upon a connective tissue cell facilitating differentiation into the osteoprogenitor cells
They adorned the scaffolding with synthetic peptides, or protein fragments, that help bone-forming cells called osteoprogenitor cells
adhere to the framework.
Regulation of Proliferation and Gene Expression in Osteoprogenitor Cells
, Osteoblasts and Osteocytes
PRF membranes protects the surgical site; promotes soft tissue healing; and when its fragments mixes with graft material, it functions as a "biological connector" between the different elements of graft and acts as a matrix which supports neoangiogenesis, capture of stem cells, and migration of osteoprogenitor cells
to the center of graft.
Osteoconductive scaffolds and osteoprogenitor cells
are the two main factors that are involved in bone tissue regeneration.
Human osteoprogenitor cells
from Lonza, #CC-2538, were cultured in Dulbecco's modified Eagle's medium with 10% fetal bovine serum.