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LANTUS(R) demonstrates a peakless and sustained concentration/time profile over 24 hours thus reducing the risk of hypoglycemia and allowing a constant and high efficacy over 24h with one single daily injection.
More analogues followed with glargine peakless insulin being approved in 2000 (2) and radically changing the therapy of type 1 diabetes.
A new long-acting insulin analogue, insulin glargine, is the first true basal insulin, providing 24-hour, peakless insulin coverage and a significantly reduced risk of hypoglycemia.