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It is possible that the decrease in DHAP content influences changes in the contents of pentose phosphate pathway metabolites such as S7P and ribulose 5-phosphate (Ru5P).
Metabolites participating in the glycolytic and pentose phosphate pathways are schematically shown.
Relative concentration of metabolites further demonstrated that HIF1 induced activation of glycolysis metabolism and pentose phosphate pathway and inhibited mitochondrial oxidation in macrophages in Lysm HIF1[alpha] lsl mice (Figure 3).
FWGE also inhibits the enzyme glucose-6-phosphate dehydrogenase (G6PDFI), a metabolic enzyme essential for using glucose carbons to make ribose through the pentose phosphate pathway mentioned above.
In a rat model Dhur et al.22 demonstrated that severe and moderate iron deprivation might result in a stimulation of G6PD and 6PGD activities per million erythrocytes and even moderate iron deficiency may alter fundamental enzymatic systems intervening in drug metabolism and in the pentose phosphate pathway. However we could not find any statistical differences between IDA patients with mild moderate and severe anemia and healthy subjects regarding plasma G6PD and6PGD activities in our study.Our study has two main limitations.
NADPH is then generated via the pentose phosphate pathway. Methylene blue however, is contraindicated in G6PD deficiency since the reduction of met-Hb by methylene blue is dependent upon NADPH generated by G6PD.
Sugars are also needed for performing antioxidative processes like pentose phosphate pathway [3,8] and carotenoid biosynthesis.
Glucose-6-phosphate dehydrogenase (G6PD, EC 1.1.1.49, [beta]-D-glucose-6-phosphate; NADP oxidoreductase) is the initial and the key regulatory enzyme in the pentose phosphate pathway [1-4].
G6PD is the enzyme catalyzing the first and the rate limiting step in pentose phosphate pathway. The latter is the dominant form of glycolysis in red cells.
G6PDH catalyzes the first step in the pentose phosphate pathway that produces reduced nicotinamide adenine dinucleotide (NADPH), needed for the maintenance of reduced glutathione and reductive biosynthesis.
McLean, "The functional significance of the pentose phosphate pathway in synaptosomes: protection against peroxidative damage by catecholamines and oxidants," Journal of Neurochemistry, vol.
Deficiency of thiamine leads to decreased activity of the enzyme transketolase in the absence of which there is reduced activity of the pentose phosphate pathway leading to the accumulation of deleterious products of glucose metabolism like ROS, AGEs, PKC etc.