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Seeger, "Nocturnal periodic breathing in primary pulmonary hypertension," European Respiratory Journal, vol.
Respiratory characteristics, transitional NREM sleep and concordance comparison ID GA PBP AI TRANSP NREMCON 1 35 2 9.0 17 60 2 38 3 2.7 7 80 3 34 2.8 4.1 13 60 4 38 3 5.7 11 80 5 36 2 6.0 10 80 6 38 2.5 7.0 13 60 7 38 3.5 3.7 3 100 8 34 3.4 3.2 8 100 9 39 2 1.1 14 60 10 38 1.8 2.4 12 60 11 38 2 6.8 4 100 12 37 2.5 3.2 11 80 13 38 3.2 5.0 14 60 14 38 2.5 5.9 8 100 15 38 3.2 7.8 5 100 16 38 3.3 2.9 10 80 17 38 2 6.6 14 60 18 38 1.8 4.6 13 100 19 38 2.6 8.6 9 100 20 38 3 3.3 7 100 21 37 1 1.7 0 100 22 38 1.5 3.1 6 80 ID: patient identifier; GA: gestational age; PBP: periodic breathing percentage; AI: apnea index; TRANSP: transitional sleep percentage, NREMCON: non-rapid eye movement sleep concordance between EEG pattern and behavior
In these individuals, pharyngeal obstruction occurs when ventilatory drive reaches a nadir during induced periodic breathing. (16-18) Likewise, using fiberoptic nasopharyngoscopy, Badr et al (19) have shown, that central apnoea is associated with pharyngeal narrowing or occlusion early (<10 sec) during the central apnoeic period and even in the absence of inspiratory efforts.
Theoretical models of periodic breathing. New York: Marcel Dekker; 2000.
Adaptive Servo Ventilation (ASV) provides ventilatory support to rapidly treat all forms of central sleep apnea (CSA), mixed apnea and periodic breathing, commonly known as Cheyne-Stokes respiration (CSR).
In these cases periodic breathing results from an unstable negative feedback control system with a combination of high loop gain (amount of change in ventilation for a given change in partial pressure of oxygen or carbon dioxide at the chemoreceptor) and a long delay between sensing a blood gas abnormality and compensating for it by adjusting ventilation.
They hypothesized that long-term improvement in periodic breathing could, in turn, improve cardiac function.

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