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Perivascular spaces surround perforating arterioles and venules as they course from the subarachnoid space through the brain parenchyma and serve as an important drainage system for interstitial fluids and solutes in the brain.
In our patient, it appeared that the meningeal component of the Cryptococcal infection involved the perivascular spaces at the base of the brain and cerebellar leptomeninges.
homing of bone marrow-derived cells that support vessel growth from the peripheral blood into the perivascular space (23,24).
In patients with CADASIL, the dilation of perivascular spaces (dPVS) throughout the brain, varying in its extent according to the cerebral location, may be promoted by the progression of the hereditary microangiopathy with aging.
The PAS-positive droplets in the perivascular spaces corresponded to glycoproteins and were probably caused by the edema formation and to active transport in astrocytes from extracellular to vascular spaces.
The earliest and most common abnormality found in patients with MPS is cystic lesions that correspond to enlargement of the Virchow-Robin perivascular spaces (PVS), which are pia-lined spaces that accompany penetrating arteries and arterioles into the brain parenchyma.
Nevertheless, in patients with ICH, blood comes into direct contact with the cerebrospinal fluid (CSF) and/or diffuses along the Virchow-Robin perivascular spaces, which according to most authors, remain in direct contact with the CSF [5, 12,17,18].
4) SPM produces a dramatic increase of endopulmonary pressure (5) that results in rupture of alveolar septa, which causes interstitial air to extend along peribronchial and perivascular spaces into the mediastinum.