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1267 HSP70-2 polymorphism as a risk factor for carotid plaque rupture and cerebral ischaemia in old type 2 diabetes-atherosclerotic patients.
Standardized extract from French maritime pine has been demonstrated to slow the progression of atherosclerotic plaques, while extracts of Centella asiatica have been found to preserve the hard, thick cap on atherosclerotic plaques--slashing the risk of a plaque rupture.
T2MI should be diagnosed when there is evidence of acute myocardial injury with necrosis, as evidenced by a rise and/or fall of cardiac troponin with at least 1 value above the 99th percentile URL, in a clinical setting consistent with overt myocardial ischemia, with an evident acute and/or sustained oxygen supply and demand imbalance, without plaque rupture within the coronary arteries, plus at least 1 other MI criterion according to the Universal Definition of MI.
On the one side, enhanced fibrosis would stabilize the plaque with a high extracellular matrix content, which may help to reduce plaque vulnerability and make plaque rupture less likely.
12 In patients with acute myocardial infarction and unstable angina, the ones suffering from plaque rupture have higher MMP-9 levels than those without, and the patients have more obvious 1562C-G polymorphism than the controls do.
In distinction, vulnerable (eg, unstable) plaque has a greater degree of lipid-laden macrophages and a less robust ECM fibrous cap (eg, non-calcified), increasing the risk for plaque rupture and in-situ thrombus formation.
Much attention is given to the acute endothelial injury and exposure of the subendothelial space to the blood resulting from the plaque rupture as the pathogenic bad actor in acute thrombus formation and infarction.
A mechanistic analysis of the role of microcalcifications in atherosclerotic plaque stability: potential implications for plaque rupture.
Plaque rupture and subsequent thrombosis at the site of the plaque rupture are the most common underlying pathophysiologic mechanisms of ACS [4,5].
Acute risk factors increase the risk of plaque rupture and cause acute cardiovascular events.
The main cause of heart attacks is due to a plaque rupture in one of the major coronary arteries, which causes a blood clot to form reducing blood flow and depriving the heart muscle downstream of oxygen rich blood.