Finkel, "Elevated platelet factor
4 and [beta]-thromboglobulin plasma levels in depressed patients with ischemic heart disease," Biological Psychiatry, vol.
Owen, Plasma levels of a-thromboglobulin and platelet factor
4 as indices of platelet activation in vivo, Blood.
This function of platelets is known as platelet procoagulant activity or 'platelet factor
Drugs induced immune destruction of platelets can be caused by two mechanisms: a drug dependent binding of Fab part of the pathological IgG with the platelets, causing their destruction, and in the second type Fab portion of the pathological IgG binds to platelet factor
For example, a small study found significantly elevated levels of platelet factor
4 among 12 depressed patients after a myocardial infarction, compared with 12 matched, nondepressed participants (Psychiatry Res.
Yet when the serum samples were tested for reactivity with antibodies, 100% of the samples reacted to platelet factor
4 bound to unfractionated heparin and to enoxaparin, but none reacted to platelet factor
4 bound to fondaparinux, Dr.
These cytokines include platelet-derived growth factor, transforming growth factor B1, platelet-derived epidermal growth factor, platelet-derived angiogenesis factor platelet factor
4, and platelet-activating factor.
We also investigated the persistence of circulating heparin-dependent antibodies by performing a platelet serotonin-release assay and an assay for anti-bodies against platelet factor
When heparin is administered to patients susceptible to HIT, an antigen complex of heparin and platelet factor
4 (PF4) is formed.
The researchers insert into the virus the gene for platelet factor
4 (PF4), a substance that stops the growth of blood vessels.
Tilley et al., "Amplification of bacteria-induced platelet activation is triggered by FcyRIIA, integrin [[alpha].sub.1][[beta.sub.3], and platelet factor
4," Blood, vol.
Testing for platelet factor
4 (H/PF4) antibodies using IgG-specific enzyme immunoassay (EIA) (Immucor) was strongly positive at 2.971 optical density (OD) units (normal range: <0.399 OD units).