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During the Mueller's maneuver, in the absence of flow, negative pleural pressure will equilibrate with lung parenchymal pressure, which will equilibrate with thoracic airway pressure, which will equilibrate with upper airway pressure.
Furthermore, although PEEP does increase right atrial pressure, the associated SVC-distending effect will be opposed by an accompanying identical or greater increase in pleural pressure (5).
Until very recently, we have been missing two vital components of the mechanics evaluation--the size of the gas-accessible compartment and the contributions of chest wall and muscle effort to the recorded airway pressure, the latter reflected by the pleural pressure.