Mutation

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Related to point mutation: Insertion mutation, Deletion mutation

MUTATION, French law. This term is synonymous with change, and is particularly applied to designate the change which takes place in the property of a thing in its transmission from one person to another; permutation therefore happens when, the owner of the thing sells, exchanges or gives it. It is nearly synonymous with transfer. (q.v.) Merl. Repert. h.t.

A Law Dictionary, Adapted to the Constitution and Laws of the United States. By John Bouvier. Published 1856.
References in periodicals archive ?
One says the data supporting the role of point mutations in cancer-gene activation are so strong that no further explanation is needed.
GBA gene is localized on chromosome 1q21, spans 7.6 kb and is composed of 11 exons and ten introns.[sup][8] To date, more than 420 mutations have been reported in GBA gene, including point mutations (missense and nonsense), deletions and insertions, splice junction mutations, frame shifts alterations, and recombinant alleles.
Influenza virus evolves through a combination of point mutations (drifts) and reassortment events (shifts) in its gene segments.
Among them are point mutations, which involve a change in a single base pair in the DNA, such as those occurring in the p53 and K-ras genes (3-5).
OPTIMAL study [sup][7] analyzed the biomarkers and found that two major EGFR mutations were the Exon 19 deletion and the Exon 21 point mutation (L858R substitution mutations), which benefited significantly more from erlotinib than chemotherapy (Exon 19 deletion, HR = 0.13; Exon 21 point mutation, HR = 0.26).
Although less frequent, at least 48 different nondeletional mutations (including point mutations and deletions/insertions of a few nucleotides), mostly located in the [alpha]2-globin gene, have also been reported as causative mutations of [[alpha].sup.+]-thalassemia (3, 4).
The most common point mutation is the A3243G mutation in tRNA leu(UUR), which is responsible for mitochondrial encephalopathy lactic acidosis, and stroke-like episodes (MELAS) syndrome and maternally inherited diabetes and deafness (MIDD).
The single patient with a F877L androgen receptor (AR) point mutation at baseline remained on treatment for 49 weeks with a partial response by RECIST.
The single patient with a F877L androgen receptor point mutation at baseline remained on treatment for 49 weeks with a partial response by RECIST.
Most cases human AI are caused by mutations of Amelx gene and it has been reported that mice with a point mutation of TRAP exhibit AI (Barron et al., 2010).
Until 2005, genetic cause of these hematological diseases was not clear.In the year 2005, a single point mutation (JAK2V617F) in the cytoplasmic tyrosine kinase JAK2 gene was proposed by several researchers in most of patients with PV, ET and PMF.4,6,10 Jak 2 gene is situated on chromosome 9p.24