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2009) SDF1/CXCR4 signalling regulates two distinct processes of precerebellar neuronal migration and its depletion leads to abnormal pontine nuclei formation.
Distinct basophilic inclusions were seen in frontal, motor, and parietal cortex, red nucleus, hypoglossal nucleus, pontine nuclei, and superior colliculus.
The neuropathology of MSA is characterised by neuronal loss, gliosis, and myelin pathology in selective brain areas including the putamen, caudate nucleus, external pallidum, substantia nigra, locus caeruleus, inferior olive, pontine nuclei, Purkinje cells of the cerebellum, and intermediate cell columns of the spinal cord.