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Due to the unexpected high frequency of pituitary abnormalities observed in one of the studies, the author suggested that the diagnostic algorithm of hyperprolactinemic states should include both polyethylene glycol (PEG) precipitation test and MRI imaging (31).
The PEG precipitation test is not perfect, but there is no doubt that modifications of it are applicable to the majority of the most widely used immunoassays for PRL, and introduction of this approach in all laboratories would largely solve the problem of macroprolactinemia.